controls carbohydrate metabolism. It drives glucose into cells,
promotes DNA replication and protein synthesis. With other hormones it controls also blood glucose level. In healthy individuals blood glucose level
varies between 80 -110 mg/ dl. Any decline below 80 mg/dl may be dangerous (hypoglycemia),
while a five fold rise
does not pose any immediate threat. Three hormones prevent a blood
glucose decline, glucagon, growth hormone and epinephrine. Insulin
removes excess blood glucose by converting it into glycogen, and
fatty acids. It promotes also the formation of fat cells and obesity.
Islet cell adenoma
Our brain requires glucose and is therefore extremely sensitive to a low blood glucose
level as will be illustrated
with the evolution
of an islet cell adenoma. It is
a benign tumor producing insulin in excess of what the body
needs. The growing tumor produces more and more insulin and blood
glucose declines until the patient sinks in coma. The disease
proceeds through two phases:
1. Compensation: When tumor is small and insulin production meager. Nevertheless insulin stimulates an increased secretion of glucagon, and growth hormone, which mobilize glucose and drive its blood level up to its normal value. Glucagon converts glycogen to glucose (glycogenolysis), and mobilizes glucose from protein (gluconeogenesis). Insulin stimulates also epinephrine which raises blood pressure (vasoconstriction) and heart rate, raising cerebral blood flow.
2. Decompensation: As tumor grows and more insulin is produced, glucagon and growth hormone fail to mobilize enough glucose, and its blood level declines. Neurons are the first to be affected since requiring glucose. Consciousness is impaired and accompanied by tremor. WOB sends the mind a signal of intense hunger as if saying :"Get sugar!" It mobilizes glucose from the periphery by cutting down its utilization. It signals the mind fatigue and muscle pain. The patient lies down stops moving, which makes more glucose available to the brain. More epinephrine is secreted, cerebral blood flow rises and so does sugar throughput.
When blood glucose becomes even lower, WOB shuts down consciousness (eliminates the mind), patient faints, glucose uptake by non vital process is cut off and diverted to vital processes in the brain stem. Increased efforts to mobilize glucose by WOB deepen unconsciousness and the patient sinks in coma.
Islet cell tumor drives hypoglycemia
The patient condition is driven by a growing islet cell tumor. As insulin production rises, and blood glucose level declines, WOB reshuffles processes to mobilize enough glucose to sustain vital processes. Each reshuffle is the most optimal WOB solution in the particular circumstances. In order to keep the patient alive, WOB sacrifices less vital processes. Fainting and coma are such solutions. They are not breakdowns, but necessary steps to keep the patient alive.
This narrative illustrates also the role of medicine
in therapy. To support
WOB and assist it where it fails.
Most patients with islet cell tumors arrive to the hospital during
decompensation (hypoglycemia), which is corrected with a glucose
infusion. When patient’s condition is stabilized, the tumor
is removed surgically.
Also the evolution of diabetes mellitus proceeds
solutions designed to maintain life at any cost .
Unfortunately medicine fails to adhere to its role as a WOB
assistant. Hyperglycemia is regarded as a failure which has to be
corrected even if it contradicts WOB.
Medicine ignores WOB messages that its treatment is false.
As the disease evolves, treatment becomes hampered by grave
side effects, 1. Bouts of hypoglycemia,
2. Obesity and hypertension, and 3. Insulin resistance. All three are WOB messages that it opposes medical treatment.
Particularly insulin resistance, which is WOB solution to
maintain hyperglycemia. WOB makes external insulin and other drugs
ineffective. Insulin resistance is a WOB solution
to maintain life despite a false medical treatment. From the WOB perspective diabetes mellitus is driven
by an rising demand for glucose by the brain. A rising
normoglycemia, and not a rising
hyperglycemia as medicine postulates
Since diabetes mellitus is about glucose craving by the brain, why not train the body to function adequately with less sugar? This may seem bizarre, yet WOB can be trained to master many unusual feats. You decide to become an athlete and start training which is a message from mind to WOB that it has to support your will. WOB will object and send messages like fatigue, or muscle pain as if saying: "Skip it!" Yet mind continues insisting. The outcome has been described elsewhere Such a feat is indicated here by the Yogi suffix. Following the example of the Hindu Yogi, who masters many involuntary processes, like breathing and heart rate, one may train to master other involuntary feats, like rope walking, or athletics, which are called respectively Circus-Yogi, and Muscle-Yogi. Insulin-Yogi can do with less insulin.
The notion of an Alcohol-Yogi, illustrates how to train WOB to handle a poison. A Cancer-Yogi trains his WOB to prolong remission.. How then to train WOB to require less glucose, and become an Insulin-Yogi? We may apply the training program of an Alcohol-Yogi.
Training to live with hypoglycemia
Imagine a healthy individual who decides to get used to rising doses of insulin. He injects himself with a small dose of insulin and immediately feels dizzy. During the following days he repeats the same treatment (training) until he does not feel dizzy anymore, whereupon he raises the insulin dose, feels dizzy again, and continues his training. Throughout his training he keeps closely a glass of sweet water in case he feels like fainting. Dizziness is a WOB message to the mind as if saying: "I fail to maintain an adequate blood glucose level, go and lie down!" You may regard it as an analog to muscle pain experienced by an athlete which is a WOB message to the mind as if saying: "I fail to grow enough muscle fibers to support your training, take a rest!"
training mimics the growth of an
islet cell adenoma. As long as WOB maintains compensation, training is effective and may continue. However when
decompensation ensues, training ought to be stopped. Above all training
has to be gradual, which applies also to the athlete. If exaggerating
he might tear a muscle or a ligament.
You may regard such an exercise as unethical. However every diabetic patient is forced to undergo a similar training. Since treatment aims to restore normoglycemia which from the WOB perspective is a hypoglycemia, medicine trains diabetic patients to become Insulin-Yogis. Every patient gets used to dizziness and sweating when he fails to adequately dose up his insulin. Many patients carry a lump of sugar to protect themselves from fainting. With time they become used to dizziness, and it stops bothering them.
Insulin damage "
In epidemiological studies of non diabetic human beings, hyperinsulinemia
has been associated with poorer cognitive performance and an increased
risk of Alzheimer's dementia" (The Lancet, 363:1253, 2003).
Yet another reason why WOB resists insulin.
Yet even an Insulin-Yogi cannot repair insulin damage. Medicine induced hypoglycemia stimulates epinephrine secretion, which promotes hypertension. Insulin itself promotes fat formation and obesity. The growing adipose tissue competes with the brain for glucose and aggravates the disease (diabesity).
" In epidemiological studies of non diabetic human beings, hyperinsulinemia has been associated with poorer cognitive performance and an increased risk of Alzheimer's dementia" (The Lancet, 363:1253, 2003). Yet another reason why WOB resists insulin.
Above all looms a glucose toxicity and its sequels. The main therapeutic objective is to slow down disease progression. The physician has to find a compromise between the rising demand of the brain for glucose, and glucose toxicity.
Medicine justifies its treatment by the outcome of clinical trials. Several studies have shown that diabetic complications decrease markedly and consistently as blood glucose levels approach 'normal' patterns over long periods. Which suggests that if a diabetic closely controls blood glucose levels the rate of diabetic complications goes down.
Clinical trials ought to be mistrusted. Their reasoning depends on machine statistics which fail when applied to humans. In such a trial the human organism is reduced to an insignificant point while in reality he is a complex and irreducible entity.