work I went to the pub. My friend Peter greeted me with an open bottle
of wine. We sat down, sipping from our glasses, and summarizing the
day. Soon he ordered another bottle.He offered me some wine yet I refused,
since feeling dizzy Despite
Peter's heavy drinking I never saw him really drunk. He won all drinking
competitions in the Pub, and passed 'lucidity tests ', like walking
along a straight line and scoring the bull's-eye.
his excessive drinking Peter was lucid and healthy. His liver tests
were normal, and I felt that even his blood alcohol level was normal.
Peter was an Alcohol-Yogi. Admiring his drinking competence I
questioned him how he mastered drinking. "Practice" was his
answer. "Train your body to consume more and more alcohol."
home I pondered what would such a training require? And how to avoid
the threat of alcohol intoxication like, liver and brain damage? Training involves
an ongoing dialog with WOB. By listening to its messages I might avoid
these stumbling blocks. First I ought to inform WOB about my intentions.
I emptied a glass of a heavy Port wine. Soon WOB objected and made me
dizzy, indicating that I reached my drinking limit. Ignoring its warning
might endanger my liver and brain. Concomitantly WOB initiated an additional
protective measure. It slowed down anti-diuretic hormone secretion,
which let my kidney generate more urine, clearing my blood of alcohol.
Twenty minutes later I watched my 'trainer molecule' disappear in the
ADH and ALDH
As I daily repeated this challenge, I realized that WOB became more and more cooperative. Soon I emptied two glasses without getting dizzy. Now WOB mobilized other protective measures: Alcohol-dehydrogenase (ADH) which converts alcohol into acet-aldehyde, and Aldehyde-dehydrogenase (ALDH) which converts acet-aldehyde into a harmless acetic acid. On top of this, WOB continued driving me to the bath room (polyuria). I wondered why is my progress so slow, and why it took WOB so long to mobilize these enzymes ?
Both enzymes are coded by two genes, ADH and ALDH. Enzyme assembly starts at the gene where RNA molecules translate the code and produce enzymes. As I intensified drinking, more enzyme molecules were required to detoxify alcohol. First, each gene raised its production rate. Upon reaching its maximal production capacity, WOB multiplied the number of the ADH and ALDH genes, creating additional assembly lines, which is known as gene amplification. All this takes time. WOB needs time to support my new drinking habit.
to acquire Peter's expertise (Yogi-hood), I exaggerated and drank too
much. Now WOB responded with an hangover, as if saying: "I cannot
cope with the rising acetaldehyde
production, cut down the liquor!". ADH transforms alcohol into
a toxic acet-aldehyde. When WOB lacks enough ALDH to detoxify it, it
sends a message of hangover. This condition is defined here as a disease
of the mind, since it was initiated by the mind and
can be cured by convincing the mind (me) to stop this folly.
Mind-WOB 'dialogue' is maintained during weight lifting. You start training
and WOB realizes that it has to strengthen the muscle. Now each muscle
unit produces more protein
(gene amplification) and thickens (hypertrophy). Upon reaching its maximal production capacity WOB creates new muscle units (hyperplasia). If you
exaggerate WOB responds with pain and other
Similar Mind-WOB dialogs are initiated whenever
we want something. Without WOB cooperation we may never realize our
will. Imagine a WOB which fails to mobilize enough ALDH, and falls to
support your wish to become an Alcohol-Yogi. Which actually happens
to some. Our will is translated by WOB into process reshuffling. Without
being aware of it, our will manipulates processes in the body,
which has important therapeutic implications.
sends WOB two kinds of messages (input) : 1. Action, and 2. Imagination.
Action characterizes our daily life. It is automatic
and unconscious. Once we change our habits or engage in new tasks
like drinking or weight lifting Mind-WOB dialog becomes conscious.
Imagination is another way to instruct WOB what we
want or expect. Like when
expecting a tasty meal, which activates processes involved in digestion.
Our image of a tasty meal is distributed by WOB to myriad cells in the
digestive tract, and liver. Mind-WOB dialog has important therapeutic
implication. Since imagination activates processes, medicine ought to find out how to activate by imagination medically important processes.
More precisely, we ought to create a mapping between input and process
same applies to WOB output which indicates disease . Here again, we
ought create a mapping between output and
a loosening of process control. These mappings
form a language for interrogating WOB during therapy.
of alcohol rises, WOB has to amplify all enzymes along the metabolic
chain, otherwise molecules may accumulate and cause damage. Then come
energy providing processes, like breathing and heart rate, which accelerate
a little. A sip of alcohol initiates a systemic
response which only WOB understands.We can grasp its intricacy only
after simplifying what is going on. Medicine focuses on the more significant
processes, and ignores the rest.
Acet-aldehyde accumulation is the most risky. It accounts for
the most conspicuous manifestation of alcoholism, like fatty
liver, cirrhosis, and dementia.
Each disease is recognized by a small number of 'deviating' processes, which ought to be regarded solely as disease indicators. Unfortunately medicine tends to regard them as causing diseases. Like hyperglycemia in diabetes, which indicates a new reshuffling (amplification) of carbohydrate metabolism. Yet medicine regards it as the main cause of diabetes, which requires treatment. Like in the case of alcohol, hyperglycemia indicates an increased glucose throughput along the carbohydrate chain. It is an indicator of this throughput, and not its cause. Diabetes involves myriad other processes, while glucose may not be its major culprit.
wonder how did WOB learn to manage alcohol? Long before man invented
fermentation and discovered wine, he carried in his gut, alcohol producing
micro-organisms. This is when WOB leaned how to detoxify acet-aldehyde.
Which might explain how our mood might be
modified by diet. Imagine a diet which encourages alcohol producing
bacteria, or vice versa. In this sense diet is also a message which
manipulates processes, not only in the gut but in the entire body.