Before reading this chapter please start with the chapters:
First Concepts.
WOB is Optimal

There are two types of diabetes; juvenile, originating in insulin shortage, and adult diabetes, manifested by insulin resistance. We shall be concerned with the second, known as non-insulin dependent diabetes mellitus.

Disease progression

Diabetes is a disease in which  carbohydrate metabolism is disturbed. It evolves along the following phases:

  1. Blood glucose rises (hyperglycemia)
  2. Loss of glucose in urine (glucosuria).
  3. More and more fat and protein are converted to glucose (glyconeogenesis).
  4. Loss of water and electrolytes. (keto-acidosis)..
  5. Blood vessel changes.
  6. Increased susceptibility to infection.
  7. Diminished blood supply to all organs, particularly to nerves (neuropathy), kidneys (nephropathy), and eye (retinopathy).
  8. Major complications: blindness, kidney failure, and coma


Diabetes results from a disturbed metabolism of carbohydrates. Carbohydrate utilization  is reduced.  Lipid and protein utilization  is increased. Blood sugar rises and is spilled out into the urine. The body loses water and electrolytes and becomes dehydrated. Diabetes progresses through two major phases : Primary
, marked by  hyperglycemia, and a secondary, during which  blood vessel changes predominate.

Primary diabetes

Blood glucose level  is controlled by two hormones, insulin which removes glucose from the blood and stores it in tissues,  and glucagon, which mobilizes sugar into the blood. When blood glucose rises (hyperglycemia), insulin increases glucose removal, glucagon reduces glucose mobilization, until the original glucose level (normoglycemia) is restored, and vice versa.

As diabetes evolves, insulin becomes less effective in removing sugar from  blood to tissues and blood glucose level rises (hyperglycemia). Which is known as insulin resistance. Either tissue receptors become abnormal, and therefore take up less glucose, or antibodies make insulin ineffective.

Secondary diabetes

Hyperglycemia damages walls of small vessels which supply blood to tissues. Usually when a tissue requires more resources, blood vessels dilate and bloodflow rises. Damaged blood vessel walls become rigid, and fail to dilate when required, which leads to relative resource shortage in tissues (ischemia). Many small blood vessels become obstructed (micro-angiopathy) and cells die (necrosis) which is manifested by retinopathy, nephropathy and neuropathy.

Who is right,  Medicine or WOB?

The section  on  disease progression is a summary of the observed diabetes, while  Pathogenesis explains its behavior. If you have read the chapter 'WOB is optimal',and accept its conclusions, you may feel somewhat uneasy. Medicine presumes that diabetes is initiated by a random metabolic error, loss of blood glucose control due to a malfunction of insulin. With time, additional random errors aggravate the disease, and initiate secondary changes. As this legend spreads, molecular biologists search for a mutated gene, which makes insulin inefficient, and starts diabetes. Medicine believes that all diseases are genetic, and start as gene mutations. 

Yet this explanation violates the principle of WOB optimality. While WOB secrets beat our understanding, we can always rely upon  its being optimal! If it seems to us as if  WOB erred, we got it all wrong since failing to grasp WOB sophistication. WOB optimality is the corner stone of medical explanation.

Three precious substances

We start with an anatomical observation, and ask which are the most important organs in our body? Obviously those who get the biggest share of resources. Check organ blood supply and you will find that the brain is the most distinguished one. Then you may ask  what are the  most precious ingredients which the brain requires? To find out, check which substances in the blood are under the tightest control? Oxygen, glucose, and calcium. When one of them becomes scarce, brain stops functioning and we faint.

Oxygen is monitored by a highly sensitive receptor linked to the brain stem. When this precious gas becomes scarce, brain accelerates respiration and heart rate, and if it fails we faint. Blood calcium level is controlled by the parathyroid hormone. The blood provides calcium to all cells and particularly to the bone, yet WOB is most obliged to the brain. When the brain requires more calcium other cells get less, and the bone releases its own calcium. Glucose control is even tighter, since it is so essential for the brain. It is controlled by several hormones , insulin, glucagon, steroids, and others . All assure that the brain gets its major share.

Yet maintaining an adequate blood concentration of these precious substances is not enough. Blood flow through the brain has to be controlled as well, which is achieved by controlling blood pressure. Elevated blood pressure raises blood flow and vice versa. It is striking that our mouth is equipped with special taste buds for sugar and salt. The latter is required for maintaining an adequate blood pressure.

New pathogenesis

Progression of diabetes is driven by the brain's rising demand for glucose, which  may be inferred from WOB behavior. Initially patient is unaware of its elevated blood sugar. Since WOB is silent patient is healthy. As demand for glucose rises, blood glucose rises too (hyperglycemia), reaching a threshold above which glucose is spilled into the urine (glucosuria). Despite the waste of glucose,  glucosuria is the most optimal (cheapest)  way to maintain equilibrium, otherwise patient might faint. Glucosuria leads to loss of fluid (polyuria), and WOB sends its first signals, like thirst, meaning:" I am losing  control of water resources, get me some water". Mind obliges, yet soon it is required to wake up several times during the night in order to pee and drink.  Patient  becomes tired and worn out, turns to the physician who finds that the urine is sweet.


He first treats hyperglycemia conservatively, instructs the patient to avoid sugar, increase protein consumption, reduce weight, and do some exercise. Hyperglycemia disappears and the patient feels better, which shows that hyperglycemia can be treated as such. Blood sugar drops since  the body requires less glucose, while brain gets its increasing share. Since the excessive brain carving for sugar has not been curbed, patient has not been cured. Disease entered a remission, which is defined as lessening in severity of the symptoms of a  disease. Since WOB is silent patient is healthy.

Exercise trains organs to utilize energy more efficiently. Weight reduction eliminates glucose utilizing cells, which leaves more glucose for the brain despite normoglycemia. As to the diet, if diabetes is driven by an increased glucose demand by the brain, sugar restriction may not be advised Do not restrict diet and let WOB select what it needs.

Insulin resistance

Since brain continues  being unsatisfied, disease progressed, and blood glucose rises. Medicine blames this rise on insulin. Less insulin is produced (relative insulin deficiency), and what is produced is deficient since it fails to lower blood glucose to its 'normal' level. Diminished effectiveness of insulin  in lowering blood sugar is called insulin resistance . Actually what insulin resists  are the expectation of  medicine,  which attempts to lower blood glucose while WOB opposes  it, and will make insulin even more resistant.

Further reading::
Four causes of daisese

How much insulin?

These arguments have far reaching implications on treatment. Although WOB continues maintaining an optimal equilibrium despite brain’s rising demands, the patient (mind) suffers. He requires more and more fluid (liters), and spends sleepless nights in the bathroom. Treatment has to establish a compromise between WOB and patient (mind). Lowering blood glucose will damage the brain, while leaving it high damages the patient. One cannot fully satisfy the patient (mind) and lower blood sugar to normal level since he will pass out.

Glucose level set point

As diabetes evolves, brain raises the blood glucose level set point, which indicates the glucose level which for the brain is 'normal' or normoglycemic. The brain determines what it regards as normoglycemia. Any blood glucose reduction below the set point is regarded by the brain as hypoglycemia. Inflicting the same damage to the brain like hypoglycemia in the non-diabetic.

The establishment of a compromise blood sugar level is the major task of the physician, who has to find out how to let the patient to enjoy life, while minimizing his brain damage.  Needless to say that medicine opposes such views and requires to lower blood sugar level to ‘normal’ values, which is an example how treatment contradicts WOB requirements.

Further reading:
WOB controls cancer


While searching for a compromise between WOB and Mind, physician can be assisted by an vital WOB skill. WOB can be trained. Since (relative) hypoglycemia is a major obstacle to an adequate therapy, why not train WOB (brain) to live with hypoglycemia in peace? It is  like training oneself to consume more and more alcohol and remain sober. Initially small amounts of alcohol make you drunk. As you drink more you gradually learn (get used) to remain sober despite the quantity. In the same way WOB can be trained to handle any poison or threat. This skill of WOB received in this site the Yogi suffix. The same as the Hindu Yogi controls many unconscious and involuntary processes, Poison-Yogi, handles excessive amounts of poison, and so does Alcohol-Yogi. Insulin-Yogi, 'remains sober' despite excessive hypoglycemia.

'Remaining sober' means that WOB does not complain, and therefore brain does not suffer from hypoglycemia. Thus,   treatment of diabetes ought to be based on  two (evolving) strategies, lowering hyperglycemia and WOB training.

Further reading

Iatrogenic medicine

Acute complications

 In acute situations, like infection, and keto-acidosis, insulin is life saving. Here  medical treatment directives are clear cut. However when the crisis is over, and disease proceeds an indolent course, treatment directives are confused. This applies to all chronic diseases. While medicine is extremely successful in treating acute conditions, it generally fails in chronic disease, particularly in secondary diabetes, when treatment is confined solely to insulin, and surgical repair of diabetic complications. Yet much more can be undertaken than that.

Alternative therapy

The main therapeutic objectives, are to induce remission and/or slow down disease progression, which can be achieved in two ways: 1. Utilize glucose more efficiently by tissues,  and  2. to divert more glucose to the brain.

Improved glucose utilization

-- Healthy eight hours natural sleep
without pills. .Patient has to learn how to sleep by himself and relax. Next comes meditation which ought to be practiced in intervals throughout the day. Then come methods for reducing worries. The patient is advised to learn these techniques from experts, and become independent.
 -- Sport lowers blood sugar by utilizing it more efficiently. Not only muscles, become more efficient but brain as well. Efficiency means, that the same effort requires less breathing and slower heart rate, two functions that require glucose. Exercise has to be gradual, since if exaggerated, sport deprives glucose from the brain, and promotes diabetes.  Medicine ought to realize that these methods are  as effective as insulin.
-- Some treatments known as Complementary Alternative Medicine (CAM
) promote more efficient glucose utilization.

Glucose diversion to the brain.

-- By training tissues to utilize glucose more efficiently more glucose is diverted to the brain.
-- However the most important way to save sugar is by reducing weight
. Obesity is the main risk factor for diabetes mellitus and  is nicknamed as diabesity  The fat tissue competes with the brain for the sugar, and promotes insulin resistance.
-- The design of an adequate diet
is not at all simple, since excessive weight reduction lowers blood glucose level, and  may harm the brain. Weight ought therefore be reduced gradually. Slim individuals do not require any diet, since glucose restriction might harm the  brain.

Then comes hygiene which prevents undesired infections. It is not at all trivial. Some soaps for instance weaken the skin barrier to microbes. One ought also  consider the skin and gut flora.

Further reading
Cancer and meditation
Microbe resistance  

Essential hypertension.

Diabetes and essential hypertension have much in common. Medicine claims that in diabetes the culprit is insulin, and that a flawed blood pressure  control drives  essential hypertension, which is called ‘The Silent Killer’. However,  the therapeutic objectives are the same: To induce remission and/or slow down disease progression

Why not assume that hypertension, like diabetes is driven by the brain?  The above arguments may then be applied also to hypertension. The major task of the physician is to establish a compromise blood pressure . Allowing  the patient to enjoy life, while minimizing his brain damage. Among other he will have to train the patient to become a Hypotension-Yogi.

Further reading:
Four causes of Disease
Etiology of disease
Cause and Etiology

An in depth study of Diabetes Mellitus

Diabetes mellitus Essential hypertension
Hyperglycemia Hypertension
Loss of fluids and minerals Fluid and salt retention
Blood vessel changes Blood vessel changes
Increased susceptibility to infection Increased susceptibility to infection
Diminished blood supply to tissues Diminished blood supply to tissues

Major complications
blindness, kidney failure and coma

Major complications
Stroke, heart failure,and kidney failure,

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