Biological age ( chapters: 11, 12, 57) has several interpretations. The present experiment highlights its relationship with health . The two CA below have the same appearance (somatic structure), yet their age structures are different. Below are their age distributions as the experiment starts.
Next, we set max age = 170. While CA-1 does not change, CA-2 differentiates. As the ages of its cells cross max age, they are set to zero (white). CA structure changes, and it differentiates.
Previously health was defined as performance of an injured system. Cell production was taken as health indicator. The more cells a CA produces, the healthier it is. An isolated CA like the two above, does not reveal its health, only its response to a challenge reveals how healthy it is. An isolated CA is also the least differentiated . The two CA depicted above vary only in their age structure. As both age, CA-2 will reach max age sooner than CA-1. It will differentiate sooner, and produce more cells, than CA-1 The sooner a CA reaches max age the healthier it is.
Throughput of a CA (process) depends on two factors: Age and max age.
The first is intrinsic to the CA (process) and the second is set by other CA (processes) and may be regarded also
as demand. A CA thrives to maximize
its throughput. Since max age is determined externally, CA thrives to maximize
its age (health)
We may now rephrase the four causes of change as follows:
When our organism is infected by a microbe, it mobilizes its defense (immune system) and attempts to eliminate it. The sooner it responds, the more favorable is the outcome. When infected again, previous experience, enables the organism to respond faster (higher throughput). These two kinds of response are known as primary (innate) and secondary (acquired) immunity. An organism equipped with secondary immunity, is healthier than that which lacks experience how to deal with a particular microbe.
This reasoning applies to all processes in the body Throughput is proportional to process health, which is represented by age. The older an isolated CA, the more abundant its resources. Yet resources may be depleted during interaction and its age velocity declines
Microbial Resistance and WOB