1: Med Hypotheses. 1981 Oct;7(10):1241-51. |
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The histogenesis of glandular neoplasia.
Zajicek G.
Tissues in the organism may be divided according to their proliferative
capacities into three categories: 1. Fast replicators (FR) e.g., epidermis; 2.
Slow replicators (SR) e.g., liver and 3. Non replicators (NR) e.g., nerve
cells. Evidence is presented that FR as well as SR tissues continuously
proliferate exhibiting two distinct histomorphological structures; a progenitor
region in which cells are formed and a functional region into which they enter.
Throughout their displacement, the cells cover a typical path denominated as
tissue radius. The SR tissues e.g., parotid gland, mammary gland, liver and
prostate, exhibit similar ontogenies, and proceed during regeneration and
neoplasia through similar stages. All are compound glands with two distinct
stem cell types, one residing in the excretory duct epithelium and the second
in the intercalated duct. Each stem cell gives rise to its typical neoplasm.
Excretory duct originating neoplasms consist of papillomas, epidermal and
adenocarcinomas, while intercalated stem cell bound neoplasms embrace the
canalicular adenoma, oncocytoma acinic cell and lobular carcinomata. All tissues
continuously stream along the tissue radius. Evidence is presented that even
the liver cords are continuously displaced from the limiting lamina toward the
terminal hepatic (or central) vein. The histological image of these tissues
actually reflects an instantaneous picture of cells in a continuous flux.
PMID: 7289895 [PubMed - indexed for MEDLINE]