: Med Hypotheses. 1980 Jun;6(6):627-37. |
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Neoplasia withstands cancer.
Zajicek G.
A theory is presented which regards cancer as a systemic disease caused by
carcinogens. The organism protects itself by mobilizing its stem cell pool
which proliferates in form of a neoplasm to withstand the deterioration of
systemic cancer. These ideas are illustrated in form of a mathematical model
which reproduces the known epidemiological functions such as: Age specific
cancer incidence, prevalence, mortality and cancer survival. Their shap
supports the theory and is consistent with the above assumptions. The model may
be utilized further for the estimation of cancer prevalence and the degree of
interaction between chronic systemic diseases and cancer. Since these features
of the model are independent of the above assumptions, it may be applied to
cancer epidemiology as such.
PMID: 7412645 [PubMed - indexed for MEDLINE]