Proliferon
The CA is controlled by the following buttons:
Start: CA are planted.
Hide CA-1 Hide CA-2
Out CA-1+: raise output rate Out CA-1-: reduce
output rate Out CA-2+: raise output rate Out CA-2-:
reduce output rate
In CA-1+: raise input rate In CA-1-:
reduce input rate In CA-2+: raise input rate
In CA-2-: reduce input rate
Infection: Infect CA-1
Information:
Input rates Output rates, Resources, Size, Illness indicator.
Proliferon is a
tissue unit in our organism. A building block from which
tissues are assembled. It is also the unit of the present
model which simulates processes in our body. Its first version
was presented previously. The
diagram depicts its present version.
Input and output rates determine the proliferon behavior.
The rates are presented as quadruplets{CA1-input, CA-1-output,
CA-2-input,CA-output), which will indicate how to set the
rates for each experiment.
1.{1,1,0,0}. Start (which means click on Start).
The proliferon settles at its maximum. Which will be called
default state. Its resources and size are maximal,
and since input rates = output rates. it maintains a steady
state, called here a solution or an attractor.
2.{0,1,0,0}. Hide CA-2 . Start. At zero input
the proliferon shrinks to Size=12. Which simulates
a medical condition known as Hypoplasia.
3.{0,1,0,0}. Hide CA-2 . Start, Infection.
Infection represents an instantaneous output initiated
by an external agent. Since CA-1 input=0 it cannot regenerate,
and remains small. It will not respond to additional Infections
since it is immune. Please note. The proliferon is healthy
and maintains a steady state |(attractor or solution). Infection
drove it from one attractor (solution) marked by size=12,
to another, marked by size = 4. This experiments illustrates
that there are two kinds of output: 1. Intended, driven by
the proliferon, and 2. Unintended, driven by the environment.
Here both are controlled by the observer.
4. {0,1,0,0}. Hide CA-2 . Start. Raise CA-1-input
to 0.1 .{0.1,1,0,0}. The proliferon will slowly return to
its default state. (since input rate > output rate) Repeat
the same with .{0.5,1,0,0} and Start. The proliferon
will regenerate faster.
5. {1,1,0.5,0}. Hide CA-2. Start The proliferon will
shrink to about the size=17. Such a response is observed in
chronic hemolytic anemia. Click on Infection. The
proliferon will shrink and then return to its previous state.
Raise the input rate .{5,1,0.5,0} There is only a slight improvement.
6. {1,1,>,0}. Hide CA-2. Start, raise gradually
the CA-1 output rate. The proliferon will shrink which has
two interpretations: 1. It shrinks since output > input
2. Yet by shrinking it delivers less, and therefore protects
its resources.
7. {1,1,0.6,0.6}. Start, both CA shrink. The proliferon
alternates between health and illness. Click several times
on Infection which hits only CA-1. Yet both respond.
8. {0.5,0.5,0.6,0.6}. Start. Since output rates >
input rates, the proliferon will soon be chronically ill.
Yet at times it may regain health. Now try {1,1,1,1} Start.
9. If you wish to help the proliferon, reduce
output and boost input, which is the motto of A
New kind of Medicine.
This simple system displays the following
properties of a complex system
1. Self organization, or organization without a central
organizing authority.
2. Emergence of an unforeseen behavior.
3 Their behavior cannot be explained by decomposing the
system into sub-parts.
4 The system is an ongoing process.
5. The system adapts creatively to unforeseen challenges
of the environment
6. In order to survive it optimizes its organization.
7. The ability of the system to perform a task is triggered
by the environment.
8. Some complex systems may propagate their design. (not
yet implemented)
Creativity is defined as an unexplained
behavior or adaptation. Optimization
is defined so: Given a set of constraints by the environment,
the system organizes itself so as to minimize their undesired
effects to it.
Some examples of complex systems:
1, The Internet.
2. Eco-system.
3. Networks like electricity and highways.
4. The metabolic network of the organism collectively
called here as Wisdom of the
Body (WOB)
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